CAPILLARIZED LIVER SINUSOIDAL ENDOTHELIAL CELLS UNDERGO PARTIAL ENDOTHELIAL-MESENCHYMAL TRANSITION TO ACTIVELY DEPOSIT SINUSOIDAL ECM IN LIVER FIBROSIS

Tissue-specific endothelial cells are more than simply a barrier lining capillaries and are proved to be capable of remarkable plasticity to become active collagen matrix-producing myofibroblasts (MFs) in solid organs with fibrosis.Liver sinusoidal endothelial cells (LSECs) also participate in the development of hepatic fibrosis, but the exact role

The number of people diagnosed with opioid use disorder has skyrocketed as a consequence of the opioid epidemic and the increased prescribing of opioid drugs for chronic pain relief.Opioid use disorder is characterized by loss of control of Dog-Leashes drug taking, continued drug use in the presence of adverse consequences, and repeated relapses to

In the studies of groundwater flow and solute transport, many efforts have been made to estimate hydrogeological parameters through physical-distance based localization schemes of ensemble assimilation approaches.However, these methods are unavailable when there are no physical distances between parameters and observations.To avoid this limitation,

3-Dimensional (3D) scanning systems are becoming more common in the industry nowadays, for inspection and reverse engineering (RE) purposes.Although technical specifications are provided with commercially available Jackets/Outerwear scanners, a question could be raised pertaining to the degree of sufficiency of the technical specifications typicall